SA
Synthetic patient 001
Oncology encounter · prototype context
Ovarian cancer FIGO III BRCA1 pathogenic Age 58
FHIR context loaded
Patient overview

Clinical context, evidence, and downstream use

Source-linked facts remain separate from derived outputs.

FHIR R4 · SMART + PKCE · mCODE · Genomics
Current clinical context

One structured oncology record supports multiple downstream workflows.

Source provenance and missingness remain visible while destination-specific rules govern trial, registry, and population outputs.
Source retained · uncertainty explicit · release rules applied
RetrieveSMART · FHIR REST · Bulk
StandardizemCODE · Genomics
EvaluateEvidence · Policy
ReleaseTrials · Registry · Population

Destination routing

patient-level source class
Structured
Oncology Record

provenance retained
Candidate trialscriterion evidence
READY
Cancer registryCCRR candidate
VALIDATE
Population analysispatient-level data blocked
BLOCKED
Audit recordrelease traceability
TRACE
6
structured oncology facts
4 observed · 2 unknown
3
candidate trials identified
0 structured contradictions
100%
released facts with provenance
synthetic fixture
1
privacy route blocked
patient → population prohibited

Longitudinal oncology record

source-linked · longitudinal · missingness visible
Jan 2026
Diagnosis
Ovarian carcinoma
Condition/cancer-001
Jan 2026
Staging
FIGO stage III
Observation/stage-001
Feb 2026
Genomics
BRCA1 pathogenic
Observation/variant-001
Current
Trial routing
candidate evidence
human review required
Current
Registry
candidate bundle
validation gate
Current
Population
aggregate only
privacy release

Evidence ledger

click source to verify
Dx
Primary cancerOvarian cancer · ICD-10-CM C56.9
St
StageFIGO Stage III
Gx
Genomic findingBRCA1 pathogenic variant
PS
ECOG performance statusNo source fact available
UNKNOWN

Provenance graph

FHIR source → structured fact
Conditioncancer-001
Observationstage-001
Observationvariant-001
Patientsynthetic-patient-001
Structured recordsource links retained
Structured oncology record

Longitudinal record with source-level verification

Facts, missingness, and transformations remain inspectable throughout the workflow.

Current structured profile

synthetic record
ConceptCanonical valueStateSource
Primary cancerOvarian cancerOBSERVED
StageFIGO Stage IIIOBSERVED
GenomicsBRCA1 pathogenicOBSERVED
ECOGUNKNOWNno source
Prior PARP inhibitorUNKNOWNinsufficient medication history

Clinical state completeness

not a risk score
72%evaluable facts
Observed4 facts

Directly represented in the synthetic FHIR source.

Unknown2 facts

Missing evidence remains visible and cannot silently become a match.

Transformation ledger

source → standardization → destination

FHIR source graph

Patient, Condition, Observation and Genomics resources remain authoritative.

FHIR R4

Structured oncology record

Standardizes clinical semantics while retaining source identifiers and uncertainty.

PROVENANCE

Registry reporting

Applies destination-specific policy, terminology, validation, and release rules.

VERIFY
Clinical trial pre-screening

Candidate trials with criterion-level evidence

Structured contradictions are excluded; unresolved criteria remain visible for protocol review.

Candidate queue

3 candidates
NCT-SYN-0010.91

BRCA-associated ovarian cancer maintenance study

Recruiting18 miPhase III
NCT-SYN-0020.78

Platinum-sensitive ovarian cancer precision study

Recruiting42 miPhase II
NCT-SYN-0030.66

Advanced gynecologic malignancy basket study

Recruiting63 miPhase II

NCT-SYN-001 evidence matrix

candidate only · final eligibility requires protocol review
Diagnosis

Ovarian cancer required

MATCH
Condition/cancer-001
Age

18–80 years

MATCH · 58
Patient/birthDate
Administrative sex

Female

MATCH
Patient/gender
BRCA1/2

Pathogenic alteration

MATCH · BRCA1
Observation/variant-001
ECOG ≤2

Performance status required

UNKNOWN
No source fact
Prior PARP inhibitor

Protocol-specific exclusion review

REQUIRES REVIEW
Medication history incomplete
4/6
criteria directly evaluable
unknowns remain explicit
0
structured hard contradictions
age and sex filters passed
2
criteria requiring human review
missing criteria remain explicit
Registry reporting

Registry candidate with validation before release

The same source facts support registry reporting without a second oncology abstraction workflow.

Registry reporting pathway

candidate package · not yet declared CCRR conformant

Source FHIR

Patient + primary cancer + stage + genomics + treatment evidence.

SOURCE

Registry candidate

The registry candidate preserves references to the original source resources.

ASSEMBLED

Validation gate

Published CCRR profile validation is required before a conformance claim or release.

PENDING EXTERNAL TEST

Source-to-report traceability

field lineage
Registry conceptSourceState
Primary site / diseaseCondition/cancer-001TRACEABLE
StageObservation/stage-001TRACEABLE
Genomic findingObservation/variant-001TRACEABLE
ECOGUnavailableMISSING

Release guardrails

Profile validationREQUIRED

Critical profile failures block a conformance claim.

Provenance completeness100%

Each current synthetic fact resolves to a source reference or explicit missingness.

Version pinningON

Published baseline and implementation-guide versions are declared rather than silently tracking latest.

Population data release

Aggregate geography without exposing patient locations

Patient-level routing is blocked before the map layer; only policy-released aggregates are rendered.

Synthetic regional aggregates
illustrative aggregate geography · not patient points
k=11 release rule
higher released aggregate
intermediate aggregate
suppressed / generalized

Privacy release gate

Direct identifiersREMOVED

Population products do not receive direct identifiers.

Patient coordinatesPROHIBITED

Raw geocoded points never enter the browser map product.

Small cellsSUPPRESSED

Low-count cells are suppressed or generalized before release.

Environmental contextAREA-LEVEL

Contextual measures are not represented as measured individual exposure.

1
patient-level route prevented
patient-level release blocked by policy
Standards & validation

Implementation and validation status

Implemented code, local tests, and external validation are deliberately separated.

FHIR R4
4.0.1
SMART App Launch
PKCE scaffold
mCODE
STU4 target
Genomics Reporting
STU3 target

Release evidence

local package validation
GateStatusInterpretation
Repository self-auditPASSpackage structure, claim boundaries, public ports
Python testsPASSunit/integration synthetic scenarios
C++ kernelsPASSdistance primitives
SMART external testPENDINGmust be executed against actual sandbox
HL7/mCODE/Genomics validationPENDINGformal validator evidence required
CCRR validationPENDINGregistry conformance not yet claimed

Audit log

prototype data
00:00:01 FHIR bundle received · tenant=setroja-prototype
00:00:01 primary cancer normalized · source=Condition/cancer-001
00:00:01 stage normalized · source=Observation/stage-001
00:00:01 genomics normalized · source=Observation/variant-001
00:00:01 ECOG unresolved · status=UNKNOWN
00:00:02 trial route permitted · human_review=true
00:00:02 registry route permitted · validator_required=true
00:00:02 population route BLOCKED_BY_POLICY · transform=aggregate_then_privacy_release
Care plan

Coordinated oncology care plan

Care tasks, unresolved data, ownership, and source status in one workspace.

4
active care-plan items
owners and source status visible
1
documentation gap
ECOG remains unresolved
4
care-team disciplines
oncology · nursing · navigation · research

Current workflow plan

prototype tasks
ItemOwnerState
Review performance-status documentation
No structured ECOG source
Care teamOPEN
Review BRCA-associated trial candidatesResearch teamREADY
Registry candidate validationRegistrarPENDING
Navigation screen follow-upNavigatorOPEN

Care team

Medical oncologytreatment oversight
Oncology nursingsymptom follow-up
Patient navigationaccess barriers and referrals
Clinical researchtrial prescreen and protocol review
Symptoms & ePRO

Patient-reported symptom monitoring

Severity and change are translated into workflow priority while clinical decisions remain with the care team.

Weekly symptom report

synthetic PRO data
NauseaCLINICAL REVIEW
FatigueMONITOR
NeuropathyMONITOR
PainMONITOR

Workflow state

Highest priorityCLINICAL REVIEW

Nausea meets the configured prototype workflow threshold.

Patient contactNOT RECORDED

Follow-up remains a care-team action, not an automated treatment decision.

Instrument governanceLOCAL CONFIG

Real-patient thresholds require validated instruments and institutional approval.

Tumor board

Multidisciplinary case review

Source facts, unresolved questions, and multidisciplinary recommendations are kept distinct.

Pre-meeting case summary

source-linked
DX
Ovarian cancerCondition/cancer-001
OBSERVED
ST
FIGO Stage IIIObservation/stage-001
OBSERVED
GX
BRCA1 pathogenic variantObservation/variant-001
OBSERVED
PS
Performance statusNo structured source
UNKNOWN

Multidisciplinary review

Medical oncologySurgical oncologyPathologyRadiologyGeneticsOncology nursingPharmacyResearchNavigationPalliative care
Board recommendation

Entered by the multidisciplinary care team. Recommendations are versioned and remain separate from source FHIR facts.

Navigation & access

Access barriers and care navigation

Transportation, financial, social, language, distance, and support needs can be surfaced for follow-up.

2
active barriers
transportation · care distance
1
high-priority need
transportation
3
support contacts
navigator · social work · financial counseling

Access screen

whole-person oncology
TransportationNEED IDENTIFIED
Financial concernsNO CURRENT NEED
Food securityNO CURRENT NEED
HousingNO CURRENT NEED
Language supportNO CURRENT NEED
Care distanceBARRIER
Caregiver supportAVAILABLE
Digital accessAVAILABLE
Prior authorizationNO ACTIVE DELAY
Insurance coverageDOCUMENTED
Survivorship & supportive care

Continuity across the cancer trajectory

Supportive care, goals of care, palliative-care status, and survivorship planning remain visible without replacing clinician judgment.

Supportive care

Symptom monitoringACTIVE

Patient-reported symptoms flow to the clinical review workspace.

Palliative careAVAILABLE

Referral status and goals-of-care documentation can be represented independently of prognosis.

Goals & preferences

Goals of care

No structured goals-of-care document is present in the current synthetic record.

NOT DOCUMENTED

Survivorship

The prototype stores survivorship plan items, late-effect domains, follow-up ownership, and source references. Diagnosis- and treatment-specific recommendations require governed clinical content.

PLAN STRUCTURE READY
Cohorts & research

Research cohort discovery

Structured disease, stage, genomics, and workflow variables can be reused for research without a second abstraction pipeline.

Cohort builder

Current synthetic cohort

1 matching patient
Patient 001MATCH

Ovarian cancer · FIGO III · BRCA1 pathogenic variant

Decision support

Consultation support with source-linked facts

Patient-friendly questions and structured facts support shared discussion without generating an autonomous treatment recommendation.

What is known

from the structured record
DX
Ovarian cancerSource: FHIR Condition
OBSERVED
ST
FIGO Stage IIISource: FHIR Observation
OBSERVED
GX
BRCA1 pathogenic variantSource: Genomics Observation
OBSERVED
PS
Performance statusNo structured source
UNKNOWN

Questions for the consultation

  1. What is the goal of the current treatment plan?
  2. Which benefits, risks, and uncertainties are most important for this decision?
  3. Are there clinical trials that should be reviewed?
  4. What symptoms or treatment effects should prompt contact with the care team?
  5. What practical barriers could affect treatment or follow-up?
Clinical boundary

Outcome estimates and treatment recommendations require validated evidence, licensed clinical content where applicable, and clinician review.